<img height="1" width="1" src="https://www.facebook.com/tr?id=1582471781774081&amp;ev=PageView &amp;noscript=1">
 
Translational Oncology Models

Accelerate PARP Inhibitor Development

Advance your targeted therapy pipeline with clinically relevant organoid and PDX platforms that model DNA repair, HRD, and synthetic lethality.

End-to-End Services

Discovery and Translation of PARP Inhibitors

Explore our in vitro and in vivo platforms for DNA repair and targeted therapy evaluation.

organoids
Organoids
Organoids for PARP Inhibitors
Patient-derived organoids model DNA repair deficiency and synthetic lethality, supporting predictive efficacy and resistance studies.
PDX Models
PDX Models
Translational In Vivo Models

Crown Bioscience’s expansive PDX collection includes BRCA, PALB2, and HRD-positive tumors to evaluate efficacy, dosing, and resistance mechanisms in clinically relevant settings.

Biomarker Identification
Biomarker Services
HRD and DDR Biomarker Profiling

Our biomarker services enable comprehensive analysis of HRD status, BRCA mutations, PARP trapping, and DDR pathway modulation.

Mechanism-of-Action Studies

Model Synthetic Lethality and DNA Repair

Evaluate PARP trapping, DNA repair inhibition, and combination effects in organoid and PDX models to uncover resistance drivers and optimize therapeutic design.

Translational Model Diversity

BRCA, PALB2, and HRD-Positive Models

Access a large panel of BRCA, PALB2, and HRD-characterized models to assess PARP inhibitor sensitivity, durability, and biomarker correlation.

Combination Therapy Evaluation

Explore Drug Combinations and Resistance

Test PARP inhibitors with immunotherapies, DDR agents, and chemotherapies to reveal synergistic effects and overcome resistance.

Biomarker Discovery

Predictive Biomarkers for PARP Response

Leverage genomic, transcriptomic, and proteomic profiling to identify response biomarkers and guide patient selection strategies.

Frequently Asked Questions

Why use organoids for PARP inhibitor testing?

Organoids provide patient-specific, genomically characterized models to study DNA repair defects, HRD, and PARP inhibitor response under controlled conditions.

How do PDX models support translational relevance?

PDX models enable evaluation of efficacy, resistance, and tumor response in vivo, reflecting patient tumor microenvironments and genetic complexity.

What biomarkers are key for PARP inhibitor research?

HRD, BRCA1/2 mutation, PALB2, ATM, PARP trapping markers, and DDR gene signatures help identify responders and track resistance emergence.

Can Crown Bioscience support PARP inhibitor combination studies?

Yes. Crown Bioscience’s integrated services allow for PARP inhibitor combination testing with chemotherapies, DDR agents, or immunotherapies across multiple model systems.

What differentiates Crown Bioscience in the field of PARP inhibitor translational development?

Crown Bioscience’s unmatched model diversity, advanced biomarker capabilities, and deep DDR expertise position Crown Bioscience as a leader in PARP inhibitor translational development.

Partner With Crown Bioscience for PARP Inhibitor Development

Connect with our oncology experts to accelerate your PARP program through integrated model systems and biomarker platforms.

Contact Us