Accelerate PARP Inhibitor Development
Advance your targeted therapy pipeline with clinically relevant organoid and PDX platforms that model DNA repair, HRD, and synthetic lethality.
Discovery and Translation of PARP Inhibitors
Explore our in vitro and in vivo platforms for DNA repair and targeted therapy evaluation.
Crown Bioscience’s expansive PDX collection includes BRCA, PALB2, and HRD-positive tumors to evaluate efficacy, dosing, and resistance mechanisms in clinically relevant settings.
Model Synthetic Lethality and DNA Repair
Evaluate PARP trapping, DNA repair inhibition, and combination effects in organoid and PDX models to uncover resistance drivers and optimize therapeutic design.
BRCA, PALB2, and HRD-Positive Models
Access a large panel of BRCA, PALB2, and HRD-characterized models to assess PARP inhibitor sensitivity, durability, and biomarker correlation.
Explore Drug Combinations and Resistance
Test PARP inhibitors with immunotherapies, DDR agents, and chemotherapies to reveal synergistic effects and overcome resistance.
Predictive Biomarkers for PARP Response
Leverage genomic, transcriptomic, and proteomic profiling to identify response biomarkers and guide patient selection strategies.
Frequently Asked Questions
Organoids provide patient-specific, genomically characterized models to study DNA repair defects, HRD, and PARP inhibitor response under controlled conditions.
PDX models enable evaluation of efficacy, resistance, and tumor response in vivo, reflecting patient tumor microenvironments and genetic complexity.
HRD, BRCA1/2 mutation, PALB2, ATM, PARP trapping markers, and DDR gene signatures help identify responders and track resistance emergence.
Yes. Crown Bioscience’s integrated services allow for PARP inhibitor combination testing with chemotherapies, DDR agents, or immunotherapies across multiple model systems.
Crown Bioscience’s unmatched model diversity, advanced biomarker capabilities, and deep DDR expertise position Crown Bioscience as a leader in PARP inhibitor translational development.
Explore Resources for PARP Inhibitor Development
Partner With Crown Bioscience for PARP Inhibitor Development
Connect with our oncology experts to accelerate your PARP program through integrated model systems and biomarker platforms.
