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Accelerate Your Biomarker Discovery

Crown Bioscience's TMA platform delivers a scalable, high-throughput solution for the discovery, validation, and screening of biomarkers in both preclinical and translational oncology research. Don’t waste time—get reliable data faster.

Accelerate Translational Oncology With Crown Bioscience TMA Technology

Tumor Tissue Microarrays (TMAs) are high-throughput, scalable tools for cancer research, enabling parallel analysis of formalin-fixed, paraffin-embedded (FFPE) tumor samples on a single slide. Our TMAs are constructed from FFPE tumor tissue sourced from our comprehensive model portfolio and curated human cancer bank. 

Crown Bioscience delivers a diverse portfolio of TMA slides—spanning HuPrime® PDX, CDX, syngeneic, MuPrime™, and clinically annotated human tumor microarrays—that accelerate biomarker discovery, biomarker validation, and translational oncology. Each array contains multiple representative cores in a standardized format, offering unmatched efficiency and reproducibility for preclinical and clinical research workflows. 

By consolidating hundreds of tissue samples onto a single slide, Crown Bioscience TMAs enable rapid, efficient analysis, bridging the gap between discovery and clinical development with greater confidence and speed.

 

What Is the Advantage of a Tumor Tissue Microarray?

This approach enables standardized staining (e.g., IHC, H&E), molecular assays, and reliable comparison across dozens—or even hundreds—of samples per slide. TMAs dramatically reduce reagent use, cut costs, improve statistical power, and streamline workflows compared to single-slide analysis.

Patient-Derived Xenograft (PDX) Models

Crown Bioscience's PDX collection consists of over 3,000+ well-characterized models that supports translational preclinical oncology research for over thirty human cancer types. Including rare indications and highly-specific molecular targets. Click a cancer type below to learn more about our models.

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Acute Lymphoblastic Leukemia
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Acute Myeloid Leukemia
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Adrenal Gland Cancer
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Bladder Cancer
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Brain Cancer
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Breast Cancer
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Cervical Cancer
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Cholangiocarcinoma
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Colorectal Cancer
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Esophageal Cancer
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Gallbladder Cancer
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Gastric Cancer
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GIST
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Head and Neck
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Kidney Cancer
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Liver Cancer
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Lung Cancer
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Lymphoma
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Melanoma
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Mesothelioma
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Metastatic Carcinoma
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Mixed Mullerian Cancer
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Ovarian Cancer
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Pancreatic Cancer
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Prostate Cancer
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Sarcoma
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Skin Cancer
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Testical Cancer
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Thyroid Cancer
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Uterine Cancer

Applications of TMAs in Biomarker Discovery and Validation

High-Throughput Tissue Analysis

TMAs allow simultaneous evaluation of biomarker prevalence across varied tumor types.

Cost-Efficient Workflows

Reagent savings and faster processing make large cohort studies viable.

Standardized, Reproducible Results

All cores on a slide undergo identical conditions, reducing variability.

Translational oncology and drug target validation

Researchers use TMAs to advance from discovery (PDX/CDX models) to clinical applicability (human TMAs).

Our TMA Model Portfolio

PDX TMAs
PDX TMAs

HuPrime® patient-derived xenograft arrays across indications like colorectal, lung, liver, melanoma, pancreatic, sarcoma—perfect for biomarker validation and preclinical insights.

CDX TMAs
CDX TMAs

Cell line-derived xenograft arrays offering homogeneous tumor microarrays for precision oncology assays.

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Syngeneic TMAs

Immunocompetent, murine syngeneic models designed for immuno-oncology research.

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MuPrime™ TMAs

Murine tumor homograft arrays that provide reproducible, high-throughput platforms.

Human TMAs
Human TMAs

Ethically sourced, clinically annotated FFPE arrays for direct translational and clinical biomarker validation.

What Are TMAs Used for in Cancer Research?

TMAs are used to rapidly screen and compare biomarker expression across multiple tumor cohorts, assess target validation, study tumor heterogeneity, and facilitate clinical translation—from preclinical PDX/CDX models to human-relevant arrays.

Which TMA Model Is Best for Biomarker Validation?

It depends on your stage and goal:

  • Start with PDX TMAs to explore sensitivity in patient-derived models.
  • Use CDX TMAs for highly reproducible, homogeneous tumor arrays.
  • Validate findings in human tumor microarrays to ensure clinical relevance.
  • For immuno-oncology, syngeneic and MuPrime™ TMAs offer immunocompetent murine contexts.
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Patient-Derived Xenograft (PDX) TMAs

Utilize TMAs derived from our extensive HuPrime® PDX models. Access tissues from colorectal, lung, pancreatic, and gastric cancer models for highly relevant preclinical studies.

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Human Clinically Annotated TMAs

Access ethically sourced and clinically annotated human TMAs, essential for clinical biomarker validation, patient stratification, and human-relevant translational research.

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Immuno-Oncology (I/O) TMAs

Screen I/O targets using TMAs built from our Syngeneic and MuPrime™ murine tumor homograft models, providing essential immunocompetent tumor tissue.

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Cell Line and Mixed TMAs

Get TMAs derived from Cell Line-Derived Xenograft models. These arrays provide mixed tumor types for broad, efficient initial screening and biomarker exploration.

Bridging Preclinical and Clinical

Validating Biomarkers and Refining Patient Stratification Strategies

Tissue microarrays are a powerful tool used by researchers to analyze expression patterns across large, diverse tumor cohorts simultaneously. By integrating our human TMAs with our robust preclinical model TMAs, researchers can confidently validate biomarkers, evaluate drug targets, and refine patient stratification strategies before entering clinical phases.

Human TMAs for Translational Research

Our human tissue microarrays are ethically sourced and clinically annotated, enabling direct application to translational studies. These FFPE human TMAs span multiple cancer indications and support:

  • Clinical biomarker validation
  • Patient stratification strategies
  • Human-relevant translational research

By integrating human TMAs with our robust preclinical model portfolio, researchers can bridge the gap between discovery and clinical development with greater confidence and efficiency.

High-Throughput, Scalable Solution

Designed for both preclinical and clinical applications, our TMAs are constructed from formalin-fixed, paraffin-embedded (FFPE) tumor tissue sourced from a comprehensive collection of murine models and a curated bank of human cancer specimens.

Our TMA portfolio includes arrays derived from:

  • HuPrime® Patient-Derived Xenograft (PDX) models
  • Cell Line-Derived Xenograft models
  • Syngeneic models
  • Murine tumor homograft (MuPrime™) models

Each TMA features two to three representative cores per model and covers diverse tumor indications. PDX TMAs span cancer types such as colorectal, gastric, lung, liver, melanoma, pancreatic, sarcoma, and more. Cell Line-Derived TMAs provide mixed tumor types for broader screening, while syngeneic and MuPrime™ TMAs offer immunocompetent and murine homograft tumor models for immuno-oncology research.

Download the TMA Catalog List 

Frequently Asked Questions

What are Tissue Microarrays (TMAs) used for in oncology?

TMAs are used for high-throughput biomarker screening, discovery, and validation in oncology. They enable the analysis of expression patterns across hundreds of tumor samples on a single slide.

Does Crown Bioscience offer Human Cancer TMAs?

Yes. Crown Bioscience offers a collection of clinically annotated human TMAs constructed from FFPE cancer tissue. These support translational and clinical research across multiple cancer indications.

What model systems are included in Crown Bioscience TMAs?

Our TMAs include tissue from Patient-Derived Xenograft (PDX), Syngeneic, Murine Homograft (MuPrime™), and Cell Line-Derived Xenograft models.

What tumor models are included in your TMAs?

We offer TMAs from patient-derived xenografts (PDX), syngeneic, and murine homograft models, covering a range of tumor types including colorectal, lung, gastric, and more.

How are TMAs used in oncology drug development?

Researchers use TMAs to validate biomarkers, evaluate drug targets, and stratify patient populations by analyzing expression patterns across tumor cohorts.

Download the TMA Catalog List