Translational Models
for Every Stage
Crown Bioscience offers a diverse range of efficacy models spanning in vitro, ex vivo, and in vivo systems. From gold standard PDX and CDX to next generation organoids, humanized, and specialty models, our platforms deliver the translational relevance needed to guide smarter drug development.
Highly translational patient-derived xenografts preserve tumor heterogeneity and enable robust drug efficacy testing and biomarker discovery to support predictive preclinical development.
Consistent and reproducible human cancer cell line xenografts for drug efficacy testing are ideal for drug response evaluation, mechanism of action studies, and reproducible benchmarking across tumor types.
Mouse models with fully intact immune systems are widely used for immuno-oncology efficacy, biomarker, and pharmacodynamic studies across a variety of tumor types and therapeutic strategies.
Specialized models include CD34+ and PBMC humanized mice as well as Humanized Genetically Modified Mouse Models, providing the translational relevance needed for biologics, IO agents, and next-generation therapies.
Advanced tumor models such as orthotopic implantation with imaging, tumor homografts, and other niche platforms, are tailored to address specific efficacy questions and unique therapeutic needs.
Leverage cell-based assays for drug screening. This solution includes OmniScreen™, Crown Bioscience’s proprietary high-throughput platform for broad efficacy evaluation across diverse tumor cell panels.
Patient-derived organoid systems provide physiologically relevant insights into drug efficacy. OrganoidXplore™ enables high-throughput screening for more predictive and translational results.
Ex vivo tumor tissue models maintain the native tumor microenvironment and immune components, delivering highly translational efficacy insights for oncology drug development.
Enhancing Efficacy With Integrated Expertise
Complement your efficacy studies with advanced analytics, biomarker discovery, PK/PD profiling, and expert consulting. These services provide the context, insights, and strategies needed to maximize translational impact.
Comprehensive drug metabolism, PK, and PD profiling ensures accurate dosing strategies. Gain insights into drug exposure, distribution, and action to drive stronger efficacy studies.
High-throughput, multiomics, and bioanalytical assays reveal biomarker-driven insights. Validate mechanisms of action and improve predictive power for clinical success.
AI-powered analytics extract meaningful efficacy insights from complex preclinical datasets. Accelerate decision-making with data-driven translational strategies.
