Find Human Biospecimen Solutions for Next-Generation Research

We maintain state-of-the-art biobanking facilities designed for optimal sample preservation and integrity, located in Hamburg and Frederick, comprised of:

• Freezer Systems
  Approximately 40 freezers operating at −80^∘C for long-term storage of plasma, serum and urine.
• Cryo Tanks
  Approximately 22 cryo tanks providing cryogenic storage at minimum −150^∘C for FF tissue.
• FFPE Cabinets
  Dedicated storage for FFPE tissue at room temperature, maintaining morphology and molecular integrity.
• Integrated Data Management
  Robust systems ensure comprehensive tracking and accessibility of all stored biospecimens.

We employ a fully traceable, barcode-based inventory system for real-time sample tracking and full chain-of-custody documentation, capturing:

• Collection timestamps
• Preservation and processing metadata
• Temperature logs during handling and storage
• Pathology verification and tumor content annotation

All biospecimens are accompanied by digitally linked clinical metadata to facilitate cohort selection, stratification, and integrative analysis.

Our biobank services stand apart with ultra-short ischemia times, ensuring unmatched traceability and reliability. Each sample is enriched with over 300 clinical data points, providing an in-depth view of patient outcomes and follow-ups. Comprehensive datasets, including tumor characteristics, therapy response, and biomarker status, empower researchers to drive meaningful insights. This commitment to high-quality, clinically annotated samples is instrumental in achieving replicable results in oncology research.

At Crown Bioscience, we understand that the quality of a biospecimen's pathology is critical for the success of your research. Our team of board-certified pathologists provides expert review and comprehensive analysis for every tissue sample, ensuring clinical relevance and providing validated data for downstream assays.

Our pathological services include:

• H&E Staining
  Every tissue biospecimen undergoes Hematoxylin and Eosin (H&E) staining, a foundational step in pathology. This allows for detailed histological review to confirm tumor presence, cellularity, and purity. This pathological verification is crucial for the reliability of any subsequent molecular analysis.
• Immunohistochemistry (IHC)
  We offer extensive IHC services to detect and localize specific proteins within the tissue. With a catalog of more than 500 pre-validated antibodies, our IHC analysis provides key insights into target expression, biomarker localization, and disease mechanisms, supporting target validation and patient stratification.
• Multiplex Immunofluorescence (mIF)
  For more complex studies, our mIF services allow for the simultaneous detection of multiple biomarkers on a single tissue section. This advanced technique provides a rich, spatial understanding of protein interactions and cellular phenotypes within the tumor microenvironment, which is essential for immuno-oncology and spatial biology research.

The future of oncology research lies in integrating data from multiple biological layers to create a holistic view of disease. Crown Bioscience’s biospecimens are the ideal starting material for multiomics research, providing the high-quality foundation needed to integrate data from genomics, transcriptomics, and proteomics.

We support multiomics research with:

• Preserved Molecular Integrity
  Our samples are collected with a minimal cold ischemia time, ensuring the integrity of DNA, RNA, and protein. This is paramount for accurate genomic sequencing, RNA expression profiling, and protein analysis.
• Integrated Clinical Data
  Each biospecimen is linked to a rich clinical data profile, including patient demographics, treatment history, and pathological findings. This comprehensive dataset allows for the correlation of multiomics data with real-world patient outcomes, enabling the discovery of clinically meaningful biomarkers.
• End-to-End Support
  We provide the expertise and infrastructure to support your entire multiomics workflow, from high-quality sample supply to bioinformatics and data analysis. This positions Crown Bioscience as a trusted partner in advancing precision oncology and accelerating drug development.

Yes, we offer custom, prospective collections to meet unique research criteria, including specific disease indications, treatment histories, and patient demographics. Our global clinical network allows us to source the precise samples you need for your project.

We use a fully traceable, barcode-based inventory system and have established, validated cold-chain logistics to ensure sample integrity from our biobank to your lab. We manage all shipping and regulatory documentation to ensure a seamless delivery process.

We support the entire biomarker discovery workflow, from initial target identification and validation using our extensive biobank to providing the high-quality, characterized samples needed for clinical validation. Our samples are suitable for multiomics profiling (genomics, transcriptomics, proteomics) to accelerate your discovery programs.

Biospecimens are critical at every stage of drug development. They are used in the early discovery phase to identify novel targets, in preclinical studies to assess drug safety and efficacy, and in clinical trials to stratify patients and monitor treatment response. The quality and characterization of these samples can directly impact the success of a drug program.

Yes. We offer fully traceable samples with robust quality control, making them ideal for the biomarker validation process. Our samples can be used to confirm that your biomarker is reliable, reproducible, and accurate in predicting a specific clinical outcome.

Our biospecimens, paired with rich clinical and pathological data, allow researchers to identify and validate predictive biomarkers that can be used to select the right patients for a clinical trial and guide the development of targeted